The Hardy-Weinberg Law:
The Hardy-Weinberg law rests on these assumptions:
• The population under study is large, and matings are random with respect to the locus in question.
• Allele frequencies remain constant over time because of the following:
• There is no appreciable rate of new mutation.
• Individuals with all genotypes are equally capable of mating and passing on their genes; that is, there is no selection against any particular genotype.
• There has been no significant immigration of individuals from a population with allele frequencies very different from the endogenous population.
A population that reasonably appears to meet these assumptions is considered to be in Hardy-Weinberg equilibrium.
Problem:
A rare disease which is due to a recessive allele (a) that is lethal when homozygous, occurs within a specific population at a frequency of one in a million. How many individuals in a town with a population of 14,000 can be expected to carry this allele?
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