Кай Саймонс (Part 1): Роль липидов в организации клеточного транспорта

Simons begins by explaining that both cholesterol and sphingolipids are made in the ER and transported to various membranes in the cell. This sorting leads to an increased concentration of cholesterol and sphingolipids in the plasma membrane relative to other membranes. In addition, cholesterol and sphingolipids tend to cluster together to form lipid rafts within the plasma membrane.