Disease Circuitry Dissection GWAS - Lecture 12 - Deep Learning in Life Science (Spring 2021)

MIT Spring 2021 Prof. Manolis Kellis Deep Learning in the Life Sciences / Computational Systems Biology Playlist: Latest slides and course today: Spring 2021 slides and materials: 00:00 Introduction 02:54 Inheritance 12:54 Genetic variation 19:15 Common and rare variants 23:34 Linkage analysis 25:25 GWAS 42:50 GWAS for Crohn’s disease 46:35 Linkage disequilibrium 48:55 Case study: FTO and obesity 1:02:00 Learning the sequence-based regulatory programs of the genome 1:08:56 Predicting the effect of variants 1:17:14 Predicting gene expression from sequence 1:21:12 Detecting Autism noncoding de novo mutation contribution