Acne vulgaris a chronic inflammatory disorder of the pilocebaceous unit.

Acne vulgaris a chronic inflammatory disorder of the pilocebaceous unit. Acne vulgaris, more commonly referred to simply as acne, is a chronic inflammatory disorder of the pilocebaceous unit. Acne vulgaris is the most common cutaneous disorder. It affects more than 17 million Americans. Patients can experience significant psychological morbidity and, rarely, mortality due to suicide. Important that physicians are familiar with Acne Vulgaris and its treatment. affects all races and ethnicities with equal significance. Darker skinned patients at increased risk for developing post-inflammatory hyper-pigmentation and keloids. Acne is polygenic and multi-factorial. Four main pathogenetic factors contribute to the disease: Propionibacterium acnes and Staphylococcus epidermidis colonisation. : bacteria found deep in follicles and stimulate the production of pro-inflammatory mediators and lipases. Inflammation and immune response. Inflammatory cells and mediators efflux into