Inadvertant intravenous injections

Intravenous Injection of Coronavirus Disease 2019 (COVID-19) mRNA Vaccine Can Induce Acute Myopericarditis in Mouse Model Background Post-vaccination myocarditis and pericarditis reported after coronavirus mRNA vaccines. The effect of accidental intravenous injection of this vaccine on the heart is unknown Methods in mice Compared difference between i.m. and i.v. injection of vaccine Clinical manifestations Histopathological changes Tissue mRNA expression Serum levels of cytokines and troponins With normal saline (NS) control Results Intravenous SARS-CoV-2 mRNA Vaccine Administration Induced Grossly Visible Pathology in Heart Only IV group developed histopathological changes of myopericarditis Evidenced by cardiomyocyte degeneration Apoptosis Necrosis with adjacent inflammatory cell infiltration Calcific deposits on visceral pericardium But Evidence of coronary artery or other cardiac pathologies was absent Spike