MIT Deep Learning Genomics - Lecture 6 - Regulatory Genomics (Spring 2020)

MIT Lecture 6. Spring 2020 Course website: Lecture slides: Lecturer: Manolis Kellis Lecture outline: 1. Biological foundations: Building blocks of Gene Regulation - Gene regulation: Cell diversity, Epigenomics, Regulators (TFs), Motifs, Disease role - Probing gene regulation: TFs/histones: ChIP-seq, Accessibility: DNase/ATAC-seq 2. Classical methods for Regulatory Genomics and Motif Discovery - Enrichment-based motif discovery: Expectation Maximization, Gibbs Sampling - E