GPCRs in VR: Endocannabinoid mechanism of action at CB1 receptors

In this video, we explore how endocannabinoids anandamide and 2-AG, as well as the phytocannabinoid THC, interact with the cannabinoid 1 receptor (CB1). CB1 is one of the most highly expressed GPCR receptors in the brain. Structures of all three ligands were compared and overlaid, and then a docking experiment was carried out using our plugin for molecular docking, which is integrated with AutoDock Smina. Thank you to our collaborators Asher Brandt, Molecular Pharmacologist at the University of Saskatchewan, Canada, and Oleg Maryaces, Director of Education at Lock & Key Remedies, Brooklyn, NY. DOWNLOAD NANOME FOR FREE Oculus: Steam: Viveport: SideQuest: SUPPORTED VR HEADSETS Oculus Rift Oculus Quest HTC Vive Complete list: CONNECT WITH US Twitter: LinkedIn: Facebook: Instagram: ABOUT NANOME Website: Step into Nanome and experience the world at the molecular level. From drug discovery to chemistry class, Nanome is a powerful tool for research and education. Visualize, design, and simulate chemical compounds, proteins, and nucleic acids like never before. Collaborate remotely in real-time, save workspaces, and share. Leading pharmaceutical and biotech companies use Nanome to accelerate drug discovery and collaborate with distributed teams across the globe. Educators at top universities use Nanome to teach chemistry in virtual reality, allowing students to explore shapes of proteins and drug compounds and to learn how these structures explain function. Be sure to also check out our blockchain platform, Matryx, which will serve as the backend IP tracking mechanism for Nanome. More info at