Pathogenesis and Treatment of Myeloma Bone Disease

Animation Description: Osteolytic bone lesions are commonly observed in patients with active multiple myeloma. For example, osteolytic bone is characterized by sparse trabeculae and is often associated with brittle bones. These bone lesions result from an imbalance which favors bone resorption and osteoclast activity over that of the osteoblasts. This imbalance is maintained through the activation or repression of multiple signaling pathways that are mediated by a variety of physical interactions between mu