Pharmacology - Diuretics - Part 1/3

Like this video? Sign up now on our website at to access 800 Exclusive videos on Basic Medical Sciences & Clinical Medicine. These are premium videos (NOT FROM YOUTUBE). All these videos come with English subtitles & download options. Sign up now! Get Lifetime Access for a one-time payment of $99 ONLY! Why sign up for premium membership? Here’s why! Membership Features for premium website members. 1. More than 800 Medical Lectures. 2. Basic Medical Sciences & Clinical Medicine. 3. Mobile-friendly interface with android and iOS apps. 4. English subtitles and new videos every week. 5. Download option for offline video playback. 6. Fanatic customer support and that’s 24/7. 7. Fast video playback option to learn faster. 8. Trusted by over 2M students in 190 countries. Pharmacology - Diuretics - Part 1/3 (0:00-2:15) Defining Diuresis & Natriuresis; Diuretic & Natriuretic agents. (2:18-7:14) Defining & describing basic structure of Nephron; normal functioning; Bowman’s Capsule, Proximal Convoluted Tubule (PCT), Loop of Henle (LOH), Distal Convoluted Tubule (DCT) & Collecting Tubule (CT). (7:16-16:30) Normal functioning of nephron; Urine formation; Importance of the processes of Filtration, Reabsorption & Active secretion. Relationship b/w Cardiac Output (CO) and Renal Blood Flow (RBF); b/w RBF & Renal Plasma Flow (RPF); b/w Glomerular Plasma Flow (GPF) & Filtration. Plasma flow per minute through renal Glomerulus/Bowman’s Capsule; Glomerular Filtration Rate (GFR). (16:35-31:44) Concepts of Filtrate, Tubular fluid etc. Final Urine Volume; percentage of fluid reabsorbed by nephron; Urine Output, normal & abnormal; Oliguria & Polyuria. Nephron as “master processor“; Acid-base balance, electrolyte balance. Drugs; Diuretics; work by altering normal mechanisms of reabsorption along the nephron. (31:51-42:40) 1-Role of PCT, 2-Role of Thick Ascending Loop of Henle (TALOH), 3-Role of DCT, 4-Role of CT. Role of PCT; Basolateral & Luminal sides of nephron cells; Reabsorption of HCO3-/alkali; maintaining acid-base balance. (42:42-1:00:22) PCT continued: Na H Counter-transporter in luminal membrane; Na K ATPases/Pumps in basolateral membrane. H2CO3(Carbonic Acid), HCO3-(Bicarbonate) & H ; Luminal Carbonic Anhydrase enzyme (CAE) & Cytosolic/Intracellular CAE. CAE blocking drugs; [Acetazolamide]; Natriuresis, Bicarbonate Uresis & Diuresis; Alkaline uresis & Acidemia.