Psychedelics in VR: A Look Inside Recent Discoveries in Psilocybin Polymorphs
Description:
In this video, we explore multiple psilocybin polymorphs and explore their structures for the first time in VR. Psilocybin has emerged as therapeutic addressing a number of neurological conditions. Its crystalline structure has heretofore remained unknown. Dr. Alex Sherwood walks us through how these polymorph structures were created and refined as well as the impact of their discovery. Improving our understanding of these polymorphs allows pharmaceutical grade characterization and predictable manufacturing consistency of the final drug product for optimal properties, on the shelf and in vivo.
References:
Sherwood, A. M. et al. Psilocybin: crystal structure solutions enable phase analysis of prior art and recently patented examples. Acta Cryst C 78, 36–55 (2022).
CCDC references: 2128419; 2128420; 2128421; 2128422; 2128423
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