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Powered by Restream This report was produced by The Rockefeller Foundation and Global Business Network. May 2010 United States Patent Curtis et al. USOO7279327B2 US 7,279,327 B2 Oct. 9, 2007 (10) Patent No.: (45) Date of Patent: (54) METHODS FOR PRODUCING RECOMBINANT CORONAVIRUS (75) Inventors: Kristopher M. Curtis, Chapel Hill, NC (US); Boyd Yount, Hillsborough, NC (US); Ralph S. Baric, Haw River, NC (US) (73) Assignee: The University of North Carolina at Chapel Hill, Chapel Hill, NC (US) (*) Notice: Subject to any disclaimer, the term of this patent is extended or adjusted under 35 . 154(b) by 33 days. (21) Appl. No.: 10/474,962 (22) PCT Filed: Apr. 19, 2002 (86). PCT No.: PCT/USO2A12453 S 371 (c)(1), (2), (4) Date: May 25, 2004 (87) PCT Pub. No.: WO02/086068 PCT Pub. Date: Oct. 31, 2002 (65) Prior Publication Data US 2004/0235132 A1 Nov. 25, 2004 Backup Channel: Band...