How does DNA fold? The loop extrusion model

The human genome is two meters long but fits inside the microscopic nucleus of a cell. How does it do this? Our work suggests that the genome forms loops and domains through a process called extrusion! For more information, see “Chromatin extrusion explains key features of loop and domain formation in wild-type and engineered genomes.“ Sanborn and Rao et al., PNAS 2015. Directed by Adrian Sanborn and Erez Aiden Animated by Najeeb Tarazi Narrated by Adrian Sanborn