Pathogenesis of Preeclampsia

Air date: Wednesday, April 08, 2009, 3:00:00 PM Category: Wednesday Afternoon Lectures Description: Imbalance of angiogenic growth factors in the maternal circulation contributes to the pathogenesis of preeclampsia. Soluble fms-like tyrosine kinase 1 (sFlt1), an endogenous anti-angiogenic protein that antagonizes vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) appears to be a central player in this paradigm. Exogenous gene transfer of sFlt1 into pregnant rats usi