Brain injury

Multifocal Necrotizing Encephalitis and Myocarditis after BNT162b2 mRNA Vaccination against COVID-19, (1 October 2022) # 76-year-old man with Parkinson’s disease Died three weeks after third COVID-19 vaccination May 2021, ChAdOx1 vaccine July 2021, Pfizer vaccine December 2021, Pfizer vaccine Family of the deceased requested an autopsy, due to ambiguous clinical signs before death. PD was confirmed by post-mortem examinations. Signs of aspiration pneumonia and systemic arteriosclerosis Histopathological analyses of the brain Acute vasculitis (predominantly lymphocytic) Multifocal necrotizing encephalitis Pronounced inflammation Glial and lymphocytic reaction In the heart Signs of chronic cardiomyopathy Mild acute lympho-histiocytic myocarditis and vasculitis Patient had no history of COVID-19 Immunohistochemistry for SARS-CoV-2