DNA and Florida

Tallahassee, Fla. State Surgeon General Dr. Joseph A. Ladapo The Surgeon General outlined concerns regarding nucleic acid contaminants Pfizer and Moderna COVID-19 mRNA vaccines, Lipid nanoparticles …. may therefore be an equally efficient vehicle for delivering contaminant DNA into human cells. The presence of SV40 promoter/enhancer DNA may also pose a unique and heightened risk of DNA integration into human cells. 2007, FDA published guidance on regulatory limits for DNA vaccines In this Guidance for Industry, the FDA outlines important considerations for vaccines that use novel methods of delivery regarding DNA integration, specifically: • DNA integration could theoretically impact a human’s oncogenes • DNA integration may result in chromosomal instability. • The Guidance for Industry discusses biodistribution of DNA vaccines and how such integration could affect unintended parts of the body including blood, heart, brain, liver, kidney, bone marrow, ovaries/testes, lung, draining lymph nodes, spleen, the site of administration at injection site. it is essential to human health to assess the risks of contaminant DNA integration into human DNA. The FDA has provided no evidence that these risks have been assessed to ensure safety. As such, Florida State Surgeon General Dr. Joseph A. Ladapo has released the following statement: “The FDA’s response does not provide data or evidence that the DNA integration assessments they recommended themselves have been performed. DNA integration poses a unique and elevated risk to human health and to the integrity of the human genome, including the risk that DNA integrated into sperm or egg gametes could be passed onto offspring of mRNA COVID-19 vaccine recipients. If the risks of DNA integration have not been assessed for mRNA COVID-19 vaccines, these vaccines are not appropriate for use in human beings. It is my hope that, in regard to COVID-19, the FDA will one day seriously consider its regulatory responsibility to protect human health, including the integrity of the human genome.” DNA fragments detected in monovalent and bivalent Pfizer/BioNTech and Moderna modRNA COVID-19 vaccines from Ontario, Canada: Exploratory dose response relationship with serious adverse events. These data demonstrate the presence of billions to hundreds of billions of DNA molecules per dose in these vaccines. Using fluorometry, all vaccines exceed the guidelines for residual DNA set by FDA and WHO of 10 ng/dose by 188 – 509-fold. In an exploratory analysis, we found preliminary evidence of a dose response relationship of the amount of DNA per dose and the frequency of serious adverse events (SAEs). Our findings extend existing concerns about vaccine safety and call into question the relevance of guidelines conceived before the introduction of efficient transfection using LNPs. World Council for Health Bacterial DNA has been found in mRNA vaccine vials. A cancer-promoting genetic sequence—SV40—has been found in the Covid-19 vaccines. This was not present in the vials used for the approval studies but has been found in all vials of the BioNTech vials disseminated for public use. Joshua Guetzkow Pfizer performed a “classic bait-and-switch” with the COVID-19 vaccine. “The first ones were made with PCR,” “which basically just replicates any DNA sequence that you give it,” whereas process 2 used E. coli, is “generally not good for us,” “They cut it up, they lay it out and then they make mRNA with it,” “Then they have to clean all that stuff out … Not only did they not do a good job at it, but it’s really unclear how well they would be able to … get it out if they really tried.”